In addition to these important nutrients, sesame seeds contain two unique substances: sesamin and sesamolin. Both of these substances belong to a group of special beneficial fibers called lignans, and have been shown to have a cholesterol-lowering effect in humans, and to prevent high blood pressure and increase vitamin E supplies in animals. Sesamin has also been found to protect the liver from oxidative damage.

Sesame is used on the surface of the bread, bakery goods, tsoureki to enrich their flavor and also for aromatic reasons. In Greece sesame is well known as a key component of traditional products and sweets like Thessaloniki bun , Lagana and the nougat.